Suma Somasekharan, Ph.D.

Affiliations: 
2008 Department of Biochemistry Kansas State University, Manhattan, KS, United States 
Area:
Physiology Biology, Biochemistry
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"Suma Somasekharan"
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John Matthew Tomich grad student 2008 Kansas State University
 (NC -1059, a channel forming peptide, induces a reversible change in barrier function of epithelial monolayers.)
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Zhang S, Zhou J, Zhang Y, et al. (2021) The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2. Communications Biology. 4: 226
Monette MY, Somasekharan S, Forbush B. (2014) Molecular motions involved in Na-K-Cl cotransporter-mediated ion transport and transporter activation revealed by internal cross-linking between transmembrane domains 10 and 11/12. The Journal of Biological Chemistry. 289: 7569-79
Somasekharan S, Monette MY, Forbush B. (2013) Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines. Plos One. 8: e82060
Somasekharan S, Tanis J, Forbush B. (2012) Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). The Journal of Biological Chemistry. 287: 17308-17
Somasekharan S, Forbush B. (2011) Functional Analysis of Transmembrane Domain 3 in NKCC1 Biophysical Journal. 100
Migliati E, Meurice N, DuBois P, et al. (2009) Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Molecular Pharmacology. 76: 105-12
Somasekharan S, Brandt R, Iwamoto T, et al. (2008) Epithelial barrier modulation by a channel forming peptide. The Journal of Membrane Biology. 222: 17-30
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