Florence M. Brunel, Ph.D.

Affiliations: 
2003 University of Louisville, Louisville, KY, United States 
Area:
Organic Chemistry, Biochemistry, Pharmacology, Pharmaceutical Chemistry
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Arno F. Spatola grad student 2003 University of Louisville
 (Alkylated C -sugars and N-methylated diketopiperazines in drug design.)
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Publications

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Brunel FM, Lewis JD, Destito G, et al. (2010) Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Letters. 10: 1093-7
Pejchal R, Gach JS, Brunel FM, et al. (2009) A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. Journal of Virology. 83: 8451-62
Medintz IL, Farrell D, Susumu K, et al. (2009) Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes. Analytical Chemistry. 81: 4831-9
Delehanty JB, Bradburne CE, Medintz IL, et al. (2009) Intracellular delivery of and sensing with quantum dot bioconjugates Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7189
Medintz IL, Pons T, Delehanty JB, et al. (2008) Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides. Bioconjugate Chemistry. 19: 1785-95
Nelson JD, Kinkead H, Brunel FM, et al. (2008) Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. Virology. 377: 170-83
Delehanty JB, Bradburne CE, Medintz IL, et al. (2008) Specific cellular delivery and intracellular fate of quantum dot-peptide and quantum dot-polymer nanoassemblies Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6866
Nelson JD, Brunel FM, Jensen R, et al. (2007) An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10. Journal of Virology. 81: 4033-43
Cardoso RM, Brunel FM, Ferguson S, et al. (2007) Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. Journal of Molecular Biology. 365: 1533-44
Delehanty JB, Medintz IL, Pons T, et al. (2007) Selective cellular delivery of self-assembled quantum dot-peptide bioconjugates Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6448
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