Christopher L. Holley, Ph.D.

Affiliations: 
2003 Duke University, Durham, NC 
Area:
Molecular Biology, Cell Biology
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Parents

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Sally Kornbluth grad student 1998-2003 Duke
 (The Drosophila Reaper protein: Links to ubiquitination and to humans.)
Jean E. Schaffer post-doc 2009-2015 Washington University, Barnes-Jewish Hospital (Cell Biology Tree)

Children

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Hsiang-Ting Ho post-doc 2016- Duke
Brittany A. Law post-doc 2016- Duke (Anatomy Tree)
Hala Abou Assi post-doc 2018- Duke
Yinzhou Zhu post-doc 2018- Duke

Collaborators

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Bryan R. Cullen collaborator (Microtree)
Stacy M. Horner collaborator
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Publications

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Abou Assi H, Rangadurai AK, Shi H, et al. (2020) 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states. Nucleic Acids Research
Gokhale NS, McIntyre ABR, Mattocks MD, et al. (2019) Altered mA Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. Molecular Cell
Courtney DG, Tsai K, Bogerd HP, et al. (2019) Epitranscriptomic Addition of mC to HIV-1 Transcripts Regulates Viral Gene Expression. Cell Host & Microbe. 26: 217-227.e6
Elliott BA, Ho HT, Ranganathan SV, et al. (2019) Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. Nature Communications. 10: 3401
Patel CB, Holley CL. (2019) Cardiac Allograft Vasculopathy: A Formidable Foe. Journal of the American College of Cardiology. 74: 52-53
Courtney DG, Chalem A, Bogerd HP, et al. (2019) Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression. Mbio. 10
Fry NJ, Law BA, Ilkayeva OR, et al. (2018) N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. Oncotarget. 9: 31231-31243
Rimer JM, Lee J, Holley CL, et al. (2018) Long-Range Function of Secreted Small Nucleolar RNAs that Direct 2'-O-Methylation. The Journal of Biological Chemistry
Fry NJ, Law BA, Ilkayeva OR, et al. (2017) N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs. Rna (New York, N.Y.)
Lee J, Harris AN, Holley CL, et al. (2016) Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. The Journal of Clinical Investigation
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