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Alexander Hoffmann

Chemistry and Biochemistry University of California, San Diego, La Jolla, CA 
signaling, transcription, computational network; stress and immune responses, apoptosis, proliferation
"Alexander Hoffmann"
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Christine S. Huang research assistant 2004-2006 UCSD
Derren Barken grad student 2007 UCSD
Jeffrey D. Kearns grad student 2009 UCSD
Shannon L. Werner grad student 2009 UCSD
Thomas Conrad grad student 2010 UCSD (Computational Biology Tree)
Ellen L. Odea grad student 2010 UCSD
Christine S. Cheng grad student 2011 UCSD
Feng-Sheng Shih grad student 2011 UCSD
Andrew B. Caldwell grad student 2014 UCSD
Karen T. Fortmann grad student 2014 UCSD
Maxim N. Shokhirev grad student 2014 UCSD
Rachel W. Tsui grad student 2014 UCSD
Brooks E. Taylor grad student 2015 UCSD
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Ando M, Magi S, Seki M, et al. (2021) IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. Npj Systems Biology and Applications. 7: 42
Luecke S, Sheu KM, Hoffmann A. (2021) Stimulus-specific responses in innate immunity: Multilayered regulatory circuits. Immunity. 54: 1915-1932
Son M, Wang AG, Tu HL, et al. (2021) NF-κB responds to absolute differences in cytokine concentrations. Science Signaling. 14
Cheng QJ, Ohta S, Sheu KM, et al. (2021) NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science (New York, N.Y.). 372: 1349-1353
Adelaja A, Taylor B, Sheu KM, et al. (2021) Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 54: 916-930.e7
Oliver Metzig M, Tang Y, Mitchell S, et al. (2020) An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions. Molecular Systems Biology. 16: e9677
Ngo KA, Kishimoto K, Davis-Turak J, et al. (2020) Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Reports. 30: 2758-2775.e6
Sen S, Cheng Z, Sheu KM, et al. (2020) Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Systems
Kim YJ, Sheu KM, Tsoi J, et al. (2020) Abstract 3155: Interferon-gamma-induced melanoma plasticity and response to PD-1 blockade therapy Cancer Research. 80: 3155-3155
Sheu K, Luecke S, Hoffmann A. (2019) Stimulus-specificity in the Responses of Immune Sentinel Cells. Current Opinion in Systems Biology. 18: 53-61
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