Charles F. Albright
Affiliations: | Vanderbilt University, Nashville, TN |
Area:
Molecular Biology, BiochemistryWebsite:
http://ir.editasmedicine.com/phoenix.zhtml?c=254265&p=irol-newsArticle&ID=2196570Google:
"Charles Albright"Bio:
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Parents
Sign in to add mentor| Phillips W. Robbins | grad student | 1989 | MIT | |
| (The use of yeast mannosyltransferases to study endoplasmic reticulum functions.) | ||||
| Robert A. Weinberg | post-doc | MIT | ||
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Publications
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| Boy KM, Guernon JM, Zuev DS, et al. (2019) Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481. Acs Medicinal Chemistry Letters. 10: 312-317 |
| Robertson AS, Iben LG, Wei C, et al. (2017) Synergistic inhibition of Aβ production by combinations of γ-secretase modulators. European Journal of Pharmacology |
| Haas LT, Salazar SV, Smith LM, et al. (2017) Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Reports. 20: 76-88 |
| Wu YJ, Guernon J, Shi J, et al. (2016) Discovery of S3-truncated, C-6 heteroaryl substituted aminothiazine β-site APP cleaving enzyme-1 (BACE1) inhibitors. Journal of Medicinal Chemistry |
| Wu YJ, Guernon J, Yang F, et al. (2016) Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents. Acs Medicinal Chemistry Letters. 7: 271-6 |
| Sankaranarayanan S, Barten DM, Vana L, et al. (2015) Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614 |
| Thakker DR, Sankaranarayanan S, Weatherspoon MR, et al. (2015) Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6931-6 |
| Toyn JH, Thompson LA, Lentz KA, et al. (2014) Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. International Journal of Alzheimer's Disease. 2014: 431858 |
| Meredith JE, Sankaranarayanan S, Guss V, et al. (2013) Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. Plos One. 8: e76523 |
| Albright CF, Dockens RC, Meredith JE, et al. (2013) Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. The Journal of Pharmacology and Experimental Therapeutics. 344: 686-95 |