David Robert Shortle, M.D., Ph.D.
Affiliations: | 1984- | Biological Chemistry | Johns Hopkins University, Baltimore, MD |
Area:
General Biophysics, BiochemistryWebsite:
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0219459/david-shortleGoogle:
"David Robert Shortle, M.D., Ph.D."Bio:
https://www.hopkinsmedicine.org/research/labs/david-shortle-lab
http://ibbsshare.bs.jhmi.edu/CVs/Shortle.pdf
Mean distance: 27.67
Parents
Sign in to add mentor| Daniel Nathans | grad student | 1979 | Johns Hopkins | |
| (Construction and characterization of SV40 mutants with single base pair substitutions at the origin of DNA synthesis.) | ||||
| David Botstein | post-doc | 1979-1982 | MIT | |
Children
Sign in to add trainee| Michael S. Ackerman | grad student | 2004 | Johns Hopkins |
| Qiaojun Fang | grad student | 2006 | Johns Hopkins |
| Erika B. Gebel | grad student | 2008 | Johns Hopkins |
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Publications
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| Shortle D. (2009) One sequence plus one mutation equals two folds. Proceedings of the National Academy of Sciences of the United States of America. 106: 21011-2 |
| Gebel EB, Shortle D. (2007) Characterization of denatured proteins using residual dipolar couplings. Methods in Molecular Biology (Clifton, N.J.). 350: 39-48 |
| Ohnishi S, Kamikubo H, Onitsuka M, et al. (2006) Conformational preference of polyglycine in solution to elongated structure. Journal of the American Chemical Society. 128: 16338-44 |
| Gebel EB, Ruan K, Tolman JR, et al. (2006) Multiple alignment tensors from a denatured protein. Journal of the American Chemical Society. 128: 9310-1 |
| Fang Q, Shortle D. (2006) Protein refolding in silico with atom-based statistical potentials and conformational search using a simple genetic algorithm. Journal of Molecular Biology. 359: 1456-67 |
| Fang Q, Shortle D. (2005) Enhanced sampling near the native conformation using statistical potentials for local side-chain and backbone interactions. Proteins. 60: 97-102 |
| Fang Q, Shortle D. (2005) A consistent set of statistical potentials for quantifying local side-chain and backbone interactions. Proteins. 60: 90-6 |
| Ohnishi S, Lee AL, Edgell MH, et al. (2004) Direct demonstration of structural similarity between native and denatured eglin C. Biochemistry. 43: 4064-70 |
| Fang Q, Shortle D. (2003) Prediction of protein structure by emphasizing local side-chain/backbone interactions in ensembles of turn fragments. Proteins. 53: 486-90 |
| Ohnishi S, Shortle D. (2003) Effects of denaturants and substitutions of hydrophobic residues on backbone dynamics of denatured staphylococcal nuclease. Protein Science : a Publication of the Protein Society. 12: 1530-7 |