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Dennis E. Discher, Ph.D.

Affiliations: 
Chemical & Biomolecular Engineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering
Website:
http://www.seas.upenn.edu/~discher/index.html
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"Dennis Discher"
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SNBCP

Children

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Harry Bermúdez grad student 2003 Penn
Paul M. Dalhaimer grad student 2003 Penn
Maureen A. Griffin grad student 2003 Penn
Kris N. Dahl grad student 2004 Penn
Richard Law grad student 2004 Penn
Peter J. Photos grad student 2004 Penn
Fariyal Ahmed grad student 2005 Penn
Nishant Bhasin grad student 2006 Penn
Adam J. Engler grad student 2006 Penn
Shyamsundar Subramanian grad student 2006 Penn
Younghoon Kim grad student 2007 Penn
Vanessa Ortiz Torres grad student 2007 Penn
Shamik Sen grad student 2007 Penn
Kandaswamy Vijayan grad student 2007 Penn
John D. Pajerowski grad student 2008 Penn
David A. Christian grad student 2009 Penn
Richard K. Tsai grad student 2009 Penn
Andre E. Brown grad student 2004-2009 Penn
Christine Carag Krieger grad student 2011 Penn
Jae-Won Shin grad student 2011 Penn
Matthew Raab grad student 2012 Penn
Pia L. Rodriguez Nunez grad student 2012 Penn
Takamasa Harada grad student 2013 Penn
Stephanie F. Majkut grad student 2013 Penn
Kyle R. Spinler grad student 2014 Penn
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Publications

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Xia Y, Cho S, Vashisth M, et al. (2018) Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods (San Diego, Calif.)
Novikova EA, Raab M, Discher DE, et al. (2018) Erratum: Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients [Phys. Rev. Lett. 118, 078103 (2017)]. Physical Review Letters. 121: 159901
Xia Y, Ivanovska IL, Zhu K, et al. (2018) Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. The Journal of Cell Biology
Chakraborty K, Vijayan K, Brown AEX, et al. (2018) Glassy worm-like micelles in solvent and shear mediated shape transitions. Soft Matter
Pfeifer CR, Xia Y, Zhu K, et al. (2018) Constricted migration increases DNA damage and independently represses cell cycle. Molecular Biology of the Cell. mbcE18020079
Cho S, Abbas A, Irianto J, et al. (2018) Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Nucleus (Austin, Tex.). 1-32
Nair P, Alvey C, Jin X, et al. (2018) Filomicelles deliver a chemo-differentiation combination of Paclitaxel and Retinoic Acid that durably represses carcinomas in liver to prolong survival. Bioconjugate Chemistry
Pfeifer CR, Alvey CM, Irianto J, et al. (2017) Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration. Current Opinion in Systems Biology. 2: 103-114
Buxboim A, Irianto J, Swift J, et al. (2017) Coordinated increase of nuclear tension and lamin-A with matrix stiffness out-competes Lamin-B Receptor which favors soft tissue phenotypes. Molecular Biology of the Cell
Deviri D, Discher DE, Safran SA. (2017) Rupture Dynamics and Chromatin Herniation in Deformed Nuclei. Biophysical Journal. 113: 1060-1071
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