Yanfei Xu, Ph.D.

Affiliations: 
2005 University of Chicago, Chicago, IL 
Area:
Molecular Biology
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"Yanfei Xu"
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John D. Crispino grad student 2005 Chicago
 (Characterization of MTB and survivin in mammalian hematopoiesis.)
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Publications

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Siu KTa, Xu Y, Swartz KL, et al. (2014) Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation Molecular and Cellular Biology. 34: 3244-3258
Xu Y, Swartz KL, Siu KT, et al. (2014) Fbw7-dependent cyclin e regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism Oncogene. 33: 3161-3171
Minella AC, Ramirez O, Xu Y, et al. (2013) Expression Of Mutant Spliceosomal Protein SF3B1 Results In Dysregulated Hematopoietic Maturation Blood. 122: 2773-2773
Siu KT, Xu Y, Bhattacharyya M, et al. (2013) Chromosome Instability Underlies Stem Cell Dysfunction and Neoplasia In Widespread Hematologic Disease Induced By Deregulated Cyclin E Blood. 122: 220-220
Siu KT, Xu Y, Bhattacharyya M, et al. (2012) A Mouse Model of Hematopoietic Stem Cell Failure Associated with p53-Loss and Defective Fbw7-Dependent Cyclin E Regulation. Blood. 120: 2297-2297
Sengupta T, Abraham G, Xu Y, et al. (2011) Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Molecular and Cellular Biology. 31: 3885-95
Xu Y, Siu KT, Verma A, et al. (2011) Cyclin E Regulation by the Fbw7 Ubiquitin Ligase Pathway Is Required for Normal Mitophagy and Restraining Reactive Oxidative Species During Erythroid Cell Maturation In Vivo Blood. 118: 3393-3393
Xu Y, Sengupta T, Kukreja L, et al. (2010) MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. The Journal of Biological Chemistry. 285: 34439-46
Xu Y, Sengupta T, Minella AC. (2010) A Screen In Primary Erythroblasts Reveals a MicroRNA-Centered Homeostatic Mechanism for Regulating Cyclin E Activity. Blood. 116: 1543-1543
Xu Y, Minella AC. (2009) A p53-Dependent, DNA Damage Response Mediates Ineffective Erythropoiesis Caused by Deregulated Cyclin E Activity. Blood. 114: 74-74
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