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Chester L. Drum, Ph.D.

Affiliations: 
2002 University of Chicago, Chicago, IL 
Area:
Molecular Biology
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"Chester Drum"
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Wei-Jen Tang grad student 2002 Chicago
 (An adenylyl cyclase exotoxin in complex with calmodulin.)

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Shen Y, Guo Q, Zhukovskaya NL, et al. (2004) Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochemical and Biophysical Research Communications. 317: 309-14
Drum CL, Yan SZ, Bard J, et al. (2002) Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 415: 396-402
Drum CL, Shen Y, Rice PA, et al. (2001) Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallographica. Section D, Biological Crystallography. 57: 1881-4
Drum CL, Yan SZ, Sarac R, et al. (2000) An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis. The Journal of Biological Chemistry. 275: 36334-40
Tang WJ, Yan S, Drum CL. (1998) Class III adenylyl cyclases: regulation and underlying mechanisms. Advances in Second Messenger and Phosphoprotein Research. 32: 137-51
Richard Benzinger G, Drum CL, Chen LQ, et al. (1997) Differences in the binding sites of two site-3 sodium channel toxins Pflugers Archiv European Journal of Physiology. 434: 742-749
Dias-Kadambi BL, Combs KA, Drum CL, et al. (1996) The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B Journal of Biological Chemistry. 271: 23828-23835
Dias-Kadambi BL, Drum CL, Hanck DA, et al. (1996) Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel Journal of Biological Chemistry. 271: 9422-9428
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