Aaron F. Carlin, Ph.D.

Affiliations: 
2007 Biomedical Sciences University of California, San Diego, La Jolla, CA 
Area:
Microbiology Biology, Immunology
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Parents

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Ajit P. Varki grad student 2007 UCSD
 (Siglec interactions with a sialylated bacterial pathogen.)
Victor Nizet grad student 2003-2007 UCSD (Microtree)
 (Siglec interactions with a sialylated bacterial pathogen)
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Publications

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Naito-Matsui Y, Davies LR, Takematsu H, et al. (2017) Physiological Exploration of the Long-term Evolutionary Selection Against Expression of N-glycolylneuraminic Acid in the Brain. The Journal of Biological Chemistry
Ali SR, Fong JJ, Carlin AF, et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. The Journal of Experimental Medicine. 211: 1231-42
Muto J, Morioka Y, Yamasaki K, et al. (2014) Hyaluronan digestion controls DC migration from the skin. The Journal of Clinical Investigation. 124: 1309-19
Shibata N, Carlin AF, Spann NJ, et al. (2013) 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. The Journal of Biological Chemistry. 288: 35812-23
Uchiyama S, Carlin AF, Khosravi A, et al. (2009) The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. The Journal of Experimental Medicine. 206: 1845-52
Weiman S, Dahesh S, Carlin AF, et al. (2009) Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 19: 1204-13
Carlin AF, Chang YC, Areschoug T, et al. (2009) Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. The Journal of Experimental Medicine. 206: 1691-9
Carlin AF, Uchiyama S, Chang YC, et al. (2009) Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 113: 3333-6
Lewis AL, Cao H, Patel SK, et al. (2007) NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. The Journal of Biological Chemistry. 282: 27562-71
Carlin AF, Lewis AL, Varki A, et al. (2007) Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. Journal of Bacteriology. 189: 1231-7
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