Angus Chen, Ph.D.
Affiliations: | 2002 | Icahn School of Medicine at Mount Sinai, New York, NY, United States |
Area:
Biochemistry, Cell Biology, Molecular BiologyGoogle:
"Angus Chen"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Zhen-Qiang Pan | grad student | 2002 | Mount Sinai School of Medicine | |
| (Ubiquitination mediated by RING finger E3 ligases.) | ||||
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Publications
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| Wu K, Yamoah K, Dolios G, et al. (2003) DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. The Journal of Biological Chemistry. 278: 28882-91 |
| Macip S, Igarashi M, Fang L, et al. (2002) Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. The Embo Journal. 21: 2180-8 |
| Chen A, Kleiman FE, Manley JL, et al. (2002) Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. The Journal of Biological Chemistry. 277: 22085-92 |
| Wu K, Chen A, Tan P, et al. (2002) The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. The Journal of Biological Chemistry. 277: 516-27 |
| Kentsis A, Dwyer EC, Perez JM, et al. (2001) The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E Journal of Molecular Biology. 312: 609-623 |
| Wu K, Chen A, Pan ZQ. (2000) Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. The Journal of Biological Chemistry. 275: 32317-24 |
| Chen A, Wu K, Fuchs SY, et al. (2000) The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. The Journal of Biological Chemistry. 275: 15432-9 |
| Wu K, Fuchs SY, Chen A, et al. (2000) The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Molecular and Cellular Biology. 20: 1382-93 |
| Fuchs SY, Chen A, Xiong Y, et al. (1999) HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene. 18: 2039-46 |
| Tan P, Fuchs SY, Chen A, et al. (1999) Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Molecular Cell. 3: 527-33 |