Shubin Sheng, Ph.D.

Affiliations: 
2007 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Molecular Biology, Pharmacology, Cell Biology
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Parents

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Benita S. Katzenellenbogen grad student 2007 UIUC
 (Estrogen receptor ligands and regulation of gene expression.)
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Publications

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Sheng S, Barnett DH, Katzenellenbogen BS. (2008) Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells. Molecular and Cellular Endocrinology. 296: 1-9
Barnett DH, Sheng S, Charn TH, et al. (2008) Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. Cancer Research. 68: 3505-15
Zhou HB, Sheng S, Compton DR, et al. (2007) Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. Journal of Medicinal Chemistry. 50: 399-403
Compton DR, Sheng S, Carlson KE, et al. (2004) Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. Journal of Medicinal Chemistry. 47: 5872-93
Muthyala RS, Ju YH, Sheng S, et al. (2004) Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorganic & Medicinal Chemistry. 12: 1559-67
Nettles KW, Sun J, Radek JT, et al. (2004) Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β: Implications for Other Nuclear Receptors Molecular Cell. 13: 317-327
Minutolo F, Antonello M, Bertini S, et al. (2003) Novel estrogen receptor ligands based on an anthranylaldoxime structure: Role of the phenol-type pseudocycle in the binding process Journal of Medicinal Chemistry. 46: 4032-4042
Harrington WR, Sheng S, Barnett DH, et al. (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Molecular and Cellular Endocrinology. 206: 13-22
Muthyala RS, Sheng S, Carlson KE, et al. (2003) Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor Journal of Medicinal Chemistry. 46: 1589-1602
Minutolo F, Antonello M, Bertini S, et al. (2003) Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors α and β Bioorganic and Medicinal Chemistry. 11: 1247-1257
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