Kristen M. Picha, Ph.D.

2000 University of Medicine and Dentistry of New Jersey, Piscataway Township, New Jersey, United States 
"Kristen Picha"
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Smita S. Patel grad student 2000 Univ. of Medicine & Dentistry of New Jersey
 (The mechanisms of dTTP hydrolysis and ssDNA binding by the T7 DNA helicase-primase and the role of magnesium(2+) in these processes.)
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Picha KM, Patel SS, Mandiyan S, et al. (2007) The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. The Journal of Biological Chemistry. 282: 2911-7
Patel SS, Picha KM. (2000) Structure and function of hexameric helicases. Annual Review of Biochemistry. 69: 651-97
Ahnert P, Picha KM, Patel SS. (2000) A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein. The Embo Journal. 19: 3418-27
Picha KM, Ahnert P, Patel SS. (2000) DNA binding in the central channel of bacteriophage T7 helicase-primase is a multistep process. Nucleotide hydrolysis is not required. Biochemistry. 39: 6401-9
Picha KM, Patel SS. (1998) Bacteriophage T7 DNA helicase binds dTTP, forms hexamers, and binds DNA in the absence of Mg2+. The presence of dTTP is sufficient for hexamer formation and DNA binding. The Journal of Biological Chemistry. 273: 27315-9
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