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Axel P. Mathieu, Ph.D.

Affiliations: 
2002 Université de Sherbrooke, Sherbrooke, Québec, Canada 
Area:
Biochemistry
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Jean-Guy LeHoux grad student 2002 Université de Sherbrooke
 (Modelisation moleculaire de la proteine "Steroidogenic Acute Regulatory" (StAR) et du cytochrome P450 17alpha-hydroxylase/17,20-Lyase (P450c17): Une approche moleculaire pour comprendre les mecanismes de la steroidogenese.)

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Publications

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Fleury A, Mathieu AP, Ducharme L, et al. (2004) Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR). The Journal of Steroid Biochemistry and Molecular Biology. 91: 259-71
Lehoux JG, Mathieu A, Lavigne P, et al. (2003) Adrenocorticotropin regulation of steroidogenic acute regulatory protein. Microscopy Research and Technique. 61: 288-99
Mathieu AP, LeHoux JG, Auchus RJ. (2003) Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities. Biochimica Et Biophysica Acta. 1619: 291-300
Mathieu AP, Lavigne P, LeHoux JG. (2002) Molecular modeling and structure-based thermodynamic analysis of the StAR protein. Endocrine Research. 28: 419-23
Mathieu AP, Fleury A, Ducharme L, et al. (2002) Insights into steroidogenic acute regulatory protein (StAR)-dependent cholesterol transfer in mitochondria: evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR. Journal of Molecular Endocrinology. 29: 327-45
Mathieu AP, Auchus RJ, LeHoux JG. (2002) Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling. The Journal of Steroid Biochemistry and Molecular Biology. 80: 99-107
Mathieu AP, Auchus RJ, LeHoux JG. (2000) Molecular modeling of the hamster adrenal P450C17. Endocrine Research. 26: 723-8
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