Kenneth M. Humphries, Ph.D.

Affiliations: 
2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Biochemistry, General Biophysics, Molecular Biology
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Luke I. Szweda grad student 2000 Case Western Medical School
 (Inhibition of NADH-linked mitochondrial respiration by 4 -hydroxy -2 -nonenal: A mechanism of free radical mediated mitochondrial dysfunction.)
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Publications

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Batushansky A, Matsuzaki S, Newhardt MF, et al. (2019) GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics : Official Journal of the Metabolomic Society. 15: 18
Pearsall EA, Cheng R, Matsuzaki S, et al. (2019) Neuroprotective effects of PPARα in retinopathy of type 1 diabetes. Plos One. 14: e0208399
Ahn B, Ranjit R, Premkumar P, et al. (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of Cachexia, Sarcopenia and Muscle
Bhaskaran S, Pharaoh G, Ranjit R, et al. (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. Embo Reports
Logan S, Pharaoh GA, Marlin MC, et al. (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular Metabolism
Bockus LB, Matsuzaki S, Vadvalkar SS, et al. (2017) Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity. Journal of the American Heart Association. 6
Pearsall EA, Cheng R, Zhou K, et al. (2017) PPARα is essential for retinal lipid metabolism and neuronal survival. Bmc Biology. 15: 113
Vadvalkar SS, Matsuzaki S, Eyster CA, et al. (2017) Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: Role of MPC2 Acetylation. The Journal of Biological Chemistry
Bastian A, Matsuzaki S, Humphries KM, et al. (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Letters
Gurley JM, Ilkayeva O, Jackson RM, et al. (2016) Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes
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