Kimon C. Kanelakis, Ph.D.

Affiliations: 
2002 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacology, Molecular Biology
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"Kimon Kanelakis"
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William B. Pratt grad student 2002 University of Michigan
 (Nucelotide binding states of hsp70 and hsp90 during assembly of heterocomplexes between the glucocorticoid receptor and hsp90.)
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Publications

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Barrett TD, Palomino HL, Brondstetter TI, et al. (2015) Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. British Journal of Pharmacology. 172: 4078-88
Lim WK, Kanelakis KC, Neubig RR. (2013) Regulation of G protein signaling by the 70kDa heat shock protein. Cellular Signalling. 25: 389-96
Barrett TD, Palomino HL, Brondstetter TI, et al. (2011) Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor. Molecular Pharmacology. 79: 910-20
Rosen MD, Venkatesan H, Peltier HM, et al. (2010) Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. Acs Medicinal Chemistry Letters. 1: 526-9
Kanelakis KC, Pyati J, Wagaman PC, et al. (2009) Functional Characterization of the Canine Heme-Regulated eIF2alpha Kinase: Regulation of Protein Synthesis. Advances in Hematology. 2009: 251915
Rosen MD, Woods CR, Goldberg SD, et al. (2009) Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorganic & Medicinal Chemistry Letters. 19: 6548-51
Kanelakis KC, Palomino HL, Li L, et al. (2009) Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases. Journal of Biomolecular Screening. 14: 627-35
Galigniana MD, Piwien Pilipuk G, Kanelakis KC, et al. (2004) Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of pregnanesteroids. Molecular and Cellular Endocrinology. 217: 167-79
Kanelakis KC, Pratt WB. (2003) Regulation of glucocorticoid receptor ligand-binding activity by the hsp90/hsp70-based chaperone machinery. Methods in Enzymology. 364: 159-73
Morishima Y, Kanelakis KC, Murphy PJ, et al. (2003) The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. The Journal of Biological Chemistry. 278: 48754-63
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