Gregory C. Ireton, Ph.D.

Affiliations: 
2003 University of Washington, Seattle, Seattle, WA 
Area:
Molecular Biology, Oncology
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"Gregory Ireton"
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Parents

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Barry L. Stoddard grad student 2003 University of Washington
 (Structural studies of yeast and bacterial cytosine deaminase: Evolution and implications for anticancer gene therapy.)
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Publications

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Mahan SD, Ireton GC, Knoeber C, et al. (2004) Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Engineering, Design & Selection : Peds. 17: 625-33
Mahan SD, Ireton GC, Stoddard BL, et al. (2004) Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference. Biochemistry. 43: 8957-64
Ireton GC, Stoddard BL. (2004) Microseed matrix screening to improve crystals of yeast cytosine deaminase. Acta Crystallographica. Section D, Biological Crystallography. 60: 601-5
Kuhlman B, Dantas G, Ireton GC, et al. (2003) Design of a novel globular protein fold with atomic-level accuracy. Science (New York, N.Y.). 302: 1364-8
Ireton GC, Black ME, Stoddard BL. (2003) The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure (London, England : 1993). 11: 961-72
Ireton GC, McDermott G, Black ME, et al. (2002) The structure of Escherichia coli cytosine deaminase. Journal of Molecular Biology. 315: 687-97
Ireton GC, Black ME, Stoddard BL. (2001) Crystallization and preliminary X-ray analysis of bacterial cytosine deaminase. Acta Crystallographica. Section D, Biological Crystallography. 57: 1643-5
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