Paul C. Spiegel, Ph.D.

2004 University of Washington, Seattle, Seattle, WA 
Molecular Biology, General Biophysics, Animal Physiology Biology
"Paul Spiegel"
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Barry L. Stoddard grad student 2004 University of Washington
 (Structural and biochemical studies of blood coagulation factor VIII and LAGLIDADG homing endonucleases.)


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Bassam G Haddad research assistant 2014-2016 Western Washington University (Neurotree)
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Brison CM, Mullen SM, Wuerth ME, et al. (2015) The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces. Plos One. 10: e0122447
Sevy AM, Healey JF, Deng W, et al. (2013) Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry. Journal of Thrombosis and Haemostasis : Jth. 11: 2128-36
Walter JD, Werther RA, Brison CM, et al. (2013) Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. Blood. 122: 4270-8
Walter JD, Werther RA, Polozova MS, et al. (2013) Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. The Journal of Biological Chemistry. 288: 9905-14
Walter JD, Hunter M, Cobb M, et al. (2012) Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4. Nucleic Acids Research. 40: 360-70
Walter JD, Littlefield P, Delbecq S, et al. (2010) Expression, purification, and analysis of unknown translation factors from Escherichia coli: A synthesis approach. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 38: 17-22
Shen BW, Spiegel PC, Chang CH, et al. (2008) The tertiary structure and domain organization of coagulation factor VIII. Blood. 111: 1240-7
Spiegel PC, Ermolenko DN, Noller HF. (2007) Elongation factor G stabilizes the hybrid-state conformation of the 70S ribosome Rna. 13: 1473-1482
Ermolenko DN, Spiegel PC, Majumdar ZK, et al. (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation Nature Structural and Molecular Biology. 14: 493-497
Ermolenko DN, Majumdar ZK, Hickerson RP, et al. (2007) Observation of Intersubunit Movement of the Ribosome in Solution Using FRET Journal of Molecular Biology. 370: 530-540
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