Abigail R. Lambert, Ph.D.

Affiliations: 
2009 University of Washington, Seattle, Seattle, WA 
Area:
Biochemistry
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Parents

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Barry L. Stoddard grad student 2009 University of Washington
 (Structure determination, thermodynamic characterization, and computational redesign of the rare-cutting restriction endonuclease NotI.)
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Publications

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Luyten YA, Hausman DE, Young JC, et al. (2022) Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Research
Lambert AR, Hallinan JP, Werther R, et al. (2020) Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition. Structure (London, England : 1993)
Niyonzima N, Lambert AR, Werther R, et al. (2017) Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses. Protein Engineering, Design & Selection : Peds. 30: 503-522
Moffett HF, Coon ME, Radtke S, et al. (2017) Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers. Nature Communications. 8: 389
Werther R, Hallinan JP, Lambert AR, et al. (2017) Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity. Nucleic Acids Research
Jacoby K, Lambert AR, Scharenberg AM. (2017) Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX). Nucleic Acids Research. 45: e11
Jacoby K, Lambert AR, Scharenberg AM. (2016) Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX). Nucleic Acids Research
Lambert AR, Hallinan JP, Shen BW, et al. (2016) Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure (London, England : 1993)
Shen BW, Lambert A, Walker BC, et al. (2015) The structural basis of asymmetry in DNA binding and cleavage as exhibited by the I-SmaMI LAGLIDADG meganuclease. Journal of Molecular Biology
Shen BW, Walker B, Lambert A, et al. (2015) The structural basis of asymmetry in DNA recognition and catalysis: binding and cleavage by the I-SmaMI meganuclease Acta Crystallographica Section a Foundations and Advances. 71: s251-s251
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