Robin D. Couch, Ph.D.

Affiliations: 
2000 University of Calgary, Calgary, Alberta, Canada 
Area:
Molecular Biology, Pharmacy, Biochemistry
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G M. Gaucher grad student 2000 University of Calgary
 (Identification and disruption of the emodin anthrone polyketide synthase gene from Aspergillus terreus.)
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Publications

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Chofor R, Sooriyaarachchi S, Risseeuw MD, et al. (2015) Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Journal of Medicinal Chemistry. 58: 2988-3001
Couch RD, Dailey A, Zaidi F, et al. (2015) Alcohol induced alterations to the human fecal VOC metabolome. Plos One. 10: e0119362
Haymond A, Johny C, Dowdy T, et al. (2014) Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). Plos One. 9: e106243
Chofor R, Risseeuw MD, Pouyez J, et al. (2014) Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro. Molecules (Basel, Switzerland). 19: 2571-87
Jackson ER, San Jose G, Brothers RC, et al. (2014) The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs. Bioorganic & Medicinal Chemistry Letters. 24: 649-53
Couch RD, Navarro K, Sikaroodi M, et al. (2013) The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome. Plos One. 8: e81163
San Jose G, Jackson ER, Uh E, et al. (2013) Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode. Medchemcomm. 4: 1099-1104
McKenney ES, Sargent M, Khan H, et al. (2012) Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy. Plos One. 7: e38167
Noto Llana M, Sarnacki SH, Vázquez MV, et al. (2012) Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice. Infection and Immunity. 80: 2231-9
Couch RD, Mott BT. (2012) Personalized medicine: changing the paradigm of drug development. Methods in Molecular Biology (Clifton, N.J.). 823: 367-78
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