Laura L. Saward, Ph.D.

Affiliations: 
2000 University of Manitoba, Winnipeg, Manitoba, Canada 
Area:
Biochemistry
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Peter Zahradka grad student 2000 University of Manitoba
 (Both the AT(1) and AT(2) receptor subtypes mediate angiotensin II-stimulated growth in vascular smooth muscle cells.)
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Publications

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Louis S, Saward L, Zahradka P. (2011) Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology. 301: H746-56
Yau L, Molnar P, Moon MC, et al. (2008) Meta-iodobenzylguanidine, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents neointimal hyperplasia. The Journal of Pharmacology and Experimental Therapeutics. 326: 717-24
Rocnik E, Saward L, Pickering JG. (2001) HSP47 expression by smooth muscle cells is increased during arterial development and lesion formation and is inhibited by fibrillar collagen. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 40-6
Wilson DP, Saward L, Zahradka P, et al. (1999) Angiotensin II receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model Cardiovascular Research. 42: 761-772
Shao Q, Saward L, Zahradka P, et al. (1998) Ca2+ mobilization in adult rat cardiomyocytes by angiotensin type 1 and 2 receptors Biochemical Pharmacology. 55: 1413-1418
Zahradka P, Yau L, Lalonde C, et al. (1998) Modulation of the vascular smooth muscle angiotensin subtype 2 (AT2) receptor by angiotensin II Biochemical and Biophysical Research Communications. 252: 476-480
Saward L, Zahradka P. (1997) Coronary artery smooth muscle in culture: Migration of heterogeneous cell populations from vessel wall Molecular and Cellular Biochemistry. 176: 53-59
Saward L, Zahradka P. (1997) Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells. Circulation Research. 81: 249-57
Saward L, Zahradka P. (1996) The angiotensin type 2 receptor mediates RNA synthesis in A10 vascular smooth muscle cells Journal of Molecular and Cellular Cardiology. 28: 499-506
Saward L, Zahradka P. (1996) Insulin is required for angiotensin II-mediated hypertrophy of smooth muscle cells Molecular and Cellular Endocrinology. 122: 93-100
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