Laura L. Saward, Ph.D.

Affiliations: 
2000 University of Manitoba, Winnipeg, Manitoba, Canada 
Area:
Biochemistry
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Peter Zahradka grad student 2000 University of Manitoba
 (Both the AT(1) and AT(2) receptor subtypes mediate angiotensin II-stimulated growth in vascular smooth muscle cells.)
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Publications

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Qiu H, Cassan R, Johnstone D, et al. (2016) Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model. Plos One. 11: e0157970
Monroe DM, Jenny RJ, Van Cott KE, et al. (2016) Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph. Advances in Hematology. 2016: 7678901
Bowler LL, Ball TB, Saward LL. (2014) A novel in vitro co-culture system allows the concurrent analysis of mature biofilm and planktonic bacteria with human lung epithelia. Journal of Microbiological Methods. 101: 49-55
Bowler LL, Zhanel GG, Ball TB, et al. (2012) Mature Pseudomonas aeruginosa biofilms prevail compared to young biofilms in the presence of ceftazidime. Antimicrobial Agents and Chemotherapy. 56: 4976-9
Louis S, Saward L, Zahradka P. (2011) Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology. 301: H746-56
Yau L, Molnar P, Moon MC, et al. (2008) Meta-iodobenzylguanidine, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents neointimal hyperplasia. The Journal of Pharmacology and Experimental Therapeutics. 326: 717-24
Wilson DP, Saward L, Zahradka P, et al. (1999) Angiotensin II receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model Cardiovascular Research. 42: 761-772
Shao Q, Saward L, Zahradka P, et al. (1998) Ca2+ mobilization in adult rat cardiomyocytes by angiotensin type 1 and 2 receptors Biochemical Pharmacology. 55: 1413-1418
Zahradka P, Yau L, Lalonde C, et al. (1998) Modulation of the vascular smooth muscle angiotensin subtype 2 (AT2) receptor by angiotensin II Biochemical and Biophysical Research Communications. 252: 476-480
Saward L, Zahradka P. (1997) Coronary artery smooth muscle in culture: Migration of heterogeneous cell populations from vessel wall Molecular and Cellular Biochemistry. 176: 53-59
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