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Nisha A. Cavanaugh, Ph.D.

Affiliations: 
2008 Chemistry University of Colorado, Boulder, Boulder, CO, United States 
Area:
Biochemistry
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Robert D. Kuchta grad student 2008 CU Boulder
 (Herpes DNA synthesis: Initiation of new DNA strands and discrimination between right and wrong bases by the polymerase.)

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Publications

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Howard MJ, Cavanaugh NA, Batra VK, et al. (2019) DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context. The Journal of Biological Chemistry
Kirby TW, DeRose EF, Cavanaugh NA, et al. (2012) Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research. 40: 2974-83
Lund TJ, Cavanaugh NA, Joubert N, et al. (2011) B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry. 50: 7243-50
Cavanaugh NA, Beard WA, Batra VK, et al. (2011) Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of Biological Chemistry. 286: 31650-60
Wilson SH, Beard WA, Shock DD, et al. (2010) Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and Molecular Life Sciences : Cmls. 67: 3633-47
Cavanaugh NA, Beard WA, Wilson SH. (2010) DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding. The Journal of Biological Chemistry. 285: 24457-65
Cavanaugh NA, Ramirez-Aguilar KA, Urban M, et al. (2009) Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Biochemistry. 48: 10199-207
Cavanaugh NA, Urban M, Beckman J, et al. (2009) Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Biochemistry. 48: 3554-64
Cavanaugh NA, Kuchta RD. (2009) Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. The Journal of Biological Chemistry. 284: 1523-32
Keller KE, Cavanaugh N, Kuchta RD. (2008) Interaction of herpes primase with the sugar of a NTP. Biochemistry. 47: 8977-84
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