Chuan-Hsiang Huang, Ph.D.

Affiliations: 
2009 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics
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L Mario Amzel grad student 2009 Johns Hopkins
 (Insights into oncogenic PIK3CA mutations from a human PI3K-alpha structure.)
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Publications

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Hoeller O, Toettcher JE, Cai H, et al. (2016) Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. Plos Biology. 14: e1002381
Gabelli SB, Huang CH, Mandelker D, et al. (2010) Structural effects of oncogenic PI3Kα mutations Current Topics in Microbiology and Immunology. 347: 43-53
Huang CH, Gabelli SB, Oldfield E, et al. (2010) Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 78: 888-99
Mandelker D, Gabelli SB, Schmidt-Kittler O, et al. (2009) A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 16996-17001
Amzel LM, Huang CH, Mandelker D, et al. (2008) Structural comparisons of class I phosphoinositide 3-kinases Nature Reviews Cancer. 8: 665-669
Huang CH, Mandelker D, Gabelli SB, et al. (2008) Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle (Georgetown, Tex.). 7: 1151-6
Huang CH, Mandelker D, Schmidt-Kittler O, et al. (2007) The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations Science. 318: 1744-1748
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