Chuan-Hsiang Huang, Ph.D.

Affiliations: 
2009 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics
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Parents

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L Mario Amzel grad student 2009 Johns Hopkins
 (Insights into oncogenic PIK3CA mutations from a human PI3K-alpha structure.)
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Publications

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Zhan H, Bhattacharya S, Cai H, et al. (2020) An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Developmental Cell
Yang JM, Bhattacharya S, West-Foyle H, et al. (2018) Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Nature Communications. 9: 4673
Schiapparelli PV, Magaña-Maldonado R, Hamilla S, et al. (2015) Abstract 4152: NKCC1 regulates migration of glioblastoma tumor initiating cells by interacting with the actin cytoskeleton Cancer Research. 75: 4152-4152
Xiong Y, Huang CH, Iglesias PA, et al. (2010) Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proceedings of the National Academy of Sciences of the United States of America. 107: 17079-86
Gabelli SB, Huang CH, Mandelker D, et al. (2010) Structural effects of oncogenic PI3Kα mutations Current Topics in Microbiology and Immunology. 347: 43-53
Huang CH, Gabelli SB, Oldfield E, et al. (2010) Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 78: 888-99
Mandelker D, Gabelli SB, Schmidt-Kittler O, et al. (2009) A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 16996-17001
Amzel LM, Huang CH, Mandelker D, et al. (2008) Structural comparisons of class I phosphoinositide 3-kinases Nature Reviews Cancer. 8: 665-669
Huang CH, Mandelker D, Gabelli SB, et al. (2008) Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle (Georgetown, Tex.). 7: 1151-6
Gabelli S, Huang C, Mandelker D, et al. (2008) Structural basis for the effects of PI3Kalpha oncogenic mutations Acta Crystallographica Section a Foundations of Crystallography. 64: C79-C80
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