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Shaun K. Olsen, Ph.D.

Affiliations: 
2006 New York University, New York, NY, United States 
Area:
Molecular Biology, Biochemistry
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Moosa Mohammadi grad student 2006 NYU
 (Structural and biochemical analysis of the molecular determinants of FGF -FGFR specificity.)

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Publications

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Beenken A, Eliseenkova AV, Ibrahimi OA, et al. (2012) Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1. The Journal of Biological Chemistry. 287: 3067-78
Kalinina J, Byron SA, Makarenkova HP, et al. (2009) Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. Molecular and Cellular Biology. 29: 4663-78
Goetz R, Beenken A, Ibrahimi OA, et al. (2007) Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Molecular and Cellular Biology. 27: 3417-28
Pitteloud N, Quinton R, Pearce S, et al. (2007) Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism Journal of Clinical Investigation. 117: 457-463
Zhang X, Ibrahimi OA, Olsen SK, et al. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. The Journal of Biological Chemistry. 281: 15694-700
Olsen SK, Li JY, Bromleigh C, et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes & Development. 20: 185-98
Mohammadi M, Olsen SK, Goetz R. (2005) A protein canyon in the FGF-FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs. Current Opinion in Structural Biology. 15: 506-16
Mohammadi M, Olsen SK, Ibrahimi OA. (2005) Structural basis for fibroblast growth factor receptor activation. Cytokine & Growth Factor Reviews. 16: 107-37
Ibrahimi OA, Yeh BK, Eliseenkova AV, et al. (2005) Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization. Molecular and Cellular Biology. 25: 671-84
Olsen SK, Ibrahimi OA, Raucci A, et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proceedings of the National Academy of Sciences of the United States of America. 101: 935-40
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