Ian M. Ahearn, Ph.D.

Affiliations: 
2010 Basic Medical Science New York University, New York, NY, United States 
Area:
Cell Biology
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Parents

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Mark R. Philips grad student 2010 NYU
 (FKBP12 regulates acylation cycling of H-Ras.)
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Publications

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Liang D, Jiang L, Bhat SA, et al. (2023) Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation. Cell Reports. 42: 111999
Deng J, Thennavan A, Dolgalev I, et al. (2021) ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nature Cancer. 2: 503-514
Ahearn IM, Court HR, Siddiqui F, et al. (2021) NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Life Science Alliance. 4
Chen X, Yao H, Kashif M, et al. (2021) A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 10
Zhou M, Kuruvilla L, Shi X, et al. (2020) Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Proceedings of the National Academy of Sciences of the United States of America
Amendola CR, Mahaffey JP, Parker SJ, et al. (2019) KRAS4A directly regulates hexokinase 1. Nature
Ahearn I, Zhou M, Philips MR. (2018) Posttranslational Modifications of RAS Proteins. Cold Spring Harbor Perspectives in Medicine
Court H, Ahearn IM, Amoyel M, et al. (2017) Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. The Journal of Cell Biology
Zhou M, Wiener H, Su W, et al. (2016) VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking. The Journal of Cell Biology
Tsai FD, Wynne JP, Ahearn IM, et al. (2014) Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation. Methods in Molecular Biology (Clifton, N.J.). 1120: 33-41
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