Zachary R. Healy, Ph.D.

Affiliations: 
2007 Johns Hopkins University, Baltimore, MD 
Area:
Chemical Engineering
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Konstantinos Konstantopoulos grad student 2007 Johns Hopkins
 (The effects of fluid shear stress on pro- and anti -inflammatory signaling in chondrocytes: Cross-talk among COX -2, the phase 2 response, and apoptosis.)
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Publications

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Healy ZR, Liu H, Holtzclaw WD, et al. (2011) Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: A potential biomarker for anti-inflammatory intervention Cancer Epidemiology Biomarkers and Prevention. 20: 1516-1523
Suganuma H, Fahey JW, Bryan KE, et al. (2011) Stimulation of phagocytosis by sulforaphane Biochemical and Biophysical Research Communications. 405: 146-151
Healy ZR, Dinkova-Kostova AT, Wehage SL, et al. (2009) Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors. Photodermatology, Photoimmunology & Photomedicine. 25: 45-50
Healy ZR, Zhu F, Stull JD, et al. (2008) Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway. American Journal of Physiology. Cell Physiology. 294: C1146-57
Talalay P, Fahey JW, Healy ZR, et al. (2007) Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation Proceedings of the National Academy of Sciences of the United States of America. 104: 17500-17505
Napier SL, Healy ZR, Schnaar RL, et al. (2007) Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands. The Journal of Biological Chemistry. 282: 3433-41
Healy ZR, Lee NH, Gao X, et al. (2005) Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis Proceedings of the National Academy of Sciences of the United States of America. 102: 14010-14015
Hardesty KJ, Healy ZR, Kensler T, et al. (2005) Identification of shear stress-responsive elements of the cyclooxygenase-2 gene in human chondrocytes Aiche Annual Meeting, Conference Proceedings. 8760
Healy ZR, Lee N, Talalay P, et al. (2005) Elucidation of intracellular signaling pathways in shear-activated chondrocytes: A role in arthritis Aiche Annual Meeting, Conference Proceedings. 8072
Abulencia JP, Gaspard R, Healy ZR, et al. (2003) Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. The Journal of Biological Chemistry. 278: 28388-94
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