K Wimalasena

Affiliations: 
Wichita State University, Wichita, KS, United States 
Area:
Biochemistry
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"K Wimalasena"
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Publications

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Lickteig B, Wimalasena VK, Wimalasena K. (2019) MPP+ Scaffold Containing Lipophilic Compounds are Potent Complex I Inhibitors and Selective Dopaminergic Toxins. Acs Chemical Neuroscience
Mapa MST, Le VQ, Wimalasena K. (2018) Characteristics of the mitochondrial and cellular uptake of MPP+, as probed by the fluorescent mimic, 4'I-MPP. Plos One. 13: e0197946
Wimalasena K. (2017) Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+ Advances in Molecular Toxicology. 11: 81-122
Kadigamuwa CC, Mapa MS, Wimalasena K. (2016) Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP(.) Chemical Research in Toxicology
Wimalasena NK, Le VQ, Wimalasena K, et al. (2016) Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. Acs Chemical Neuroscience
Wimalasena K. (2016) The inherent high vulnerability of dopaminergic neurons toward mitochondrial toxins may contribute to the etiology of Parkinson's disease. Neural Regeneration Research. 11: 246-7
Freyberg Z, Sonders MS, Aguilar JI, et al. (2016) Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain. Nature Communications. 7: 10652
Kadigamuwa CC, Le VQ, Wimalasena K. (2015) 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP⁺. Journal of Neurochemistry. 135: 755-67
Wimalasena DS, Perera RP, Heyen BJ, et al. (2008) Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. Journal of Medicinal Chemistry. 51: 760-8
Bhakta MN, Olabisi A, Wimalasena K, et al. (2008) Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid. Journal of Inorganic Biochemistry. 102: 251-9
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