Chris Dealwis

Affiliations: 
The University of Tennessee 
Area:
Biochemistry
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"Chris Dealwis"
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Publications

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Ahmad MF, Alam I, Huff SE, et al. (2017) Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proceedings of the National Academy of Sciences of the United States of America
Knappenberger AJ, Mohammed FA, Viswanathan R, et al. (2016) Nucleoside analog triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity. Biochemistry
Misko TA, Wijerathna SR, Radivoyevitch T, et al. (2016) Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. Febs Letters
Ahmad MF, Huff SE, Pink J, et al. (2015) Identification of non-nucleoside human ribonucleotide reductase modulators. Journal of Medicinal Chemistry
Wan Q, Bennett BC, Wilson MA, et al. (2014) Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 111: 18225-30
Wan Q, Kovalevsky AY, Wilson MA, et al. (2014) Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+. Acta Crystallographica. Section F, Structural Biology Communications. 70: 814-8
Ahmad MF, Dealwis CG. (2013) The structural basis for the allosteric regulation of ribonucleotide reductase. Progress in Molecular Biology and Translational Science. 117: 389-410
Ahmad MF, Wan Q, Jha S, et al. (2012) Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Molecular Cancer Therapeutics. 11: 2077-86
Ahmad MF, Kaushal PS, Wan Q, et al. (2012) Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. Journal of Molecular Biology. 419: 315-29
Wijerathna SR, Ahmad MF, Xu H, et al. (2011) Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals (Basel, Switzerland). 4: 1328-1354
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