Raji E. Joseph, Ph.D.

Affiliations: 
2004 Iowa State University, Ames, IA, United States 
Area:
Biochemistry
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"Raji Joseph"
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F A. Norris grad student 2004 Iowa State
 (Insights into the working of P -Rex2: An inositol polyphosphate 4 -phosphatase domain containing guanine nucleotide exchange factor.)
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Publications

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Chopra N, Wales TE, Joseph RE, et al. (2016) Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. Plos Computational Biology. 12: e1004826
Roberts JM, Tarafdar S, Joseph RE, et al. (2016) Dynamics of the Tec-family Tyrosine Kinase SH3 domains. Protein Science : a Publication of the Protein Society
Devkota S, Joseph RE, Min L, et al. (2015) Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. Journal of Molecular Biology
Boyken SE, Chopra N, Xie Q, et al. (2014) A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69
Joseph RE, Kleino I, Wales TE, et al. (2013) Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76
Xie Q, Joseph RE, Fulton DB, et al. (2013) Substrate recognition of PLCγ1 via a specific docking surface on Itk. Journal of Molecular Biology. 425: 683-96
Joseph RE, Ginder ND, Hoy JA, et al. (2012) Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 145-53
Joseph RE, Ginder ND, Hoy JA, et al. (2011) Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 269-73
Joseph RE, Andreotti AH. (2011) Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue. Biochemistry. 50: 221-9
Joseph RE, Xie Q, Andreotti AH. (2010) Identification of an allosteric signaling network within Tec family kinases. Journal of Molecular Biology. 403: 231-42
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