Kenolisa C. Onwueme, Ph.D.

Affiliations: 
2005 Weill Cornell Medical College, New York, NY, United States 
Area:
Microbiology Biology, Biochemistry
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"Kenolisa Onwueme"
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Luis Quadri grad student 2005 Weill Cornell Medical College
 (Biosynthesis of the polyketide synthase-derived phthiocerol dimycocerosate virulence factors of Mycobacterium tuberculosis.)
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Publications

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Chavadi SS, Onwueme KC, Edupuganti UR, et al. (2012) The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids. Microbiology (Reading, England). 158: 1379-87
Onwueme KC, Vos CJ, Zurita J, et al. (2005) The dimycocerosate ester polyketide virulence factors of mycobacteria. Progress in Lipid Research. 44: 259-302
Onwueme KC, Vos CJ, Zurita J, et al. (2005) Identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factors. Journal of Bacteriology. 187: 4760-6
Buglino J, Onwueme KC, Ferreras JA, et al. (2004) Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 279: 30634-42
Onwueme KC, Ferreras JA, Buglino J, et al. (2004) Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5. Proceedings of the National Academy of Sciences of the United States of America. 101: 4608-13
Biggins JB, Onwueme KC, Thorson JS. (2003) Resistance to enediyne antitumor antibiotics by CalC self-sacrifice. Science (New York, N.Y.). 301: 1537-41
Flowers A, Onwueme K, Creveling CR, et al. (2002) Reserpine: interactions with batrachotoxin and brevetoxin sites on voltage-dependent sodium channels. Cellular and Molecular Neurobiology. 22: 1-12
Thorson JS, Sievers EL, Ahlert J, et al. (2000) Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research. Current Pharmaceutical Design. 6: 1841-79
Wood JL, Stoltz BM, Goodman SN, et al. (1997) Design and implementation of an efficient synthetic approach to pyranosylated indolocarbazoles: Total synthesis of (+)-RK286c, (+)-MLR-52, (+)-staurosporine, and (-)-TAN-1030a Journal of the American Chemical Society. 119: 9652-9661
Wood JL, Stoltz BM, Onwueme K, et al. (1996) The synthesis of desamido analogs of staurosporine, RK-286c, and TAN-1030a Tetrahedron Letters. 37: 7335-7338
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