Leonard D. Spicer
Affiliations: | Biochemistry | Duke University, Durham, NC |
Area:
Biochemistry, Microbiology BiologyGoogle:
"Leonard Spicer"Children
Sign in to add trainee| Anne M. Augustus | grad student | 2009 | Duke |
| Patrick N. Reardon | grad student | 2011 | Duke |
| Sophie Gobeil | post-doc | (Chemistry Tree) |
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Publications
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| Gobeil SM, Bobay BG, Juvvadi PR, et al. (2021) Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio. e0300021 |
| Juvvadi PR, Bobay BG, Gobeil SMC, et al. (2020) FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochemical and Biophysical Research Communications |
| Juvvadi PR, Fox D, Bobay BG, et al. (2019) Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nature Communications. 10: 4275 |
| Gobeil SMC, Bobay BG, Spicer LD, et al. (2019) N, C and H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. Biomolecular Nmr Assignments |
| Tonthat NK, Juvvadi PR, Zhang H, et al. (2016) Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio. 7 |
| Reardon PN, Sage H, Dennison SM, et al. (2014) Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer. Proceedings of the National Academy of Sciences of the United States of America. 111: 1391-6 |
| Robinson KE, Reardon PN, Spicer LD. (2012) In-cell NMR spectroscopy in Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 831: 261-77 |
| Augustus AM, Spicer LD. (2011) The MetJ regulon in gammaproteobacteria determined by comparative genomics methods. Bmc Genomics. 12: 558 |
| Augustus AM, Sage H, Spicer LD. (2010) Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions. Biochemistry. 49: 3289-95 |
| Augustus AM, Reardon PN, Spicer LD. (2009) MetJ repressor interactions with DNA probed by in-cell NMR. Proceedings of the National Academy of Sciences of the United States of America. 106: 5065-9 |