Brad C. Bennett, Ph.D.

Affiliations: 
2005 The University of Tennessee, Knoxville, TN, United States 
Area:
Biochemistry, Pharmaceutical Chemistry
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Chris Dealwis grad student 2005 University of Tennessee
 (High resolution x-ray and neutron crystallographic studies of Escherichia coli dihydrofolate reductase.)
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Publications

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Wan Q, Bennett BC, Wymore T, et al. (2021) Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis. Acs Catalysis. 11: 5873-5884
Wan Q, Bennett BC, Wilson MA, et al. (2014) Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 111: 18225-30
Purdy MD, Bennett BC, McIntire WE, et al. (2014) Function and dynamics of macromolecular complexes explored by integrative structural and computational biology. Current Opinion in Structural Biology. 27: 138-48
Wan Q, Kovalevsky AY, Wilson MA, et al. (2014) Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+. Acta Crystallographica. Section F, Structural Biology Communications. 70: 814-8
Lee SC, Bennett BC, Hong WX, et al. (2013) Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E1203-11
Bennett B, Purdy M, Baker K, et al. (2013) X-Ray Structure of the Cx26 Gap Junction Channel and Comparison with the Cryo-EM Structure of Cx43 Biophysical Journal. 104: 42a-43a
Miyagi M, Wan Q, Ahmad MF, et al. (2011) Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Plos One. 6: e17055
Bennett BC, Yeager M. (2010) The lighter side of a sweet reaction. Structure (London, England : 1993). 18: 657-9
Bennett BC, Wan Q, Ahmad MF, et al. (2009) X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. Journal of Structural Biology. 166: 162-71
Bennett BC, Gardberg AS, Blair MD, et al. (2008) On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study. Acta Crystallographica. Section D, Biological Crystallography. 764-83
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