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Shoghag B. Panjarian, Ph.D.

Affiliations: 
2012 Medicine University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacology
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Thomas E. Smithgall grad student 2012 University of Pittsburgh
 (Investigating allosteric regulation of ABL and BCR-ABL kinases: Implications for small molecule inhibitors.)

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Publications

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Panjarian S, Madzo J, Slater C, et al. (2019) Abstract P3-05-03: Identification of epigenetically silenced breast cancer driver genes Cancer Research. 79
Good CR, Panjarian S, Kelly AD, et al. (2018) TET1-mediated hypomethylation activates oncogenic signaling in triple-negative breast cancer. Cancer Research
Sato T, Cesaroni M, Chung W, et al. (2016) Transcriptional Selectivity of Epigenetic Therapy in Cancer. Cancer Research
Badger J, Grover P, Panjarian SB, et al. (2016) The c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution. Biochemistry
Sato T, Cesaroni M, Tran A, et al. (2016) Abstract B42: Decitabine specifically targets genes that gain DNA methylation and lose expression in cancer and can be combined with histone methylation inhibitors for increased efficacy Cancer Research. 76
Sato T, Cesaroni M, Panjarian S, et al. (2016) Abstract 2657: Target specificity of epigenetic therapy in cancer Cancer Research. 76: 2657-2657
Panjarian S, Iacob RE, Chen S, et al. (2013) Structure and dynamic regulation of Abl kinases. The Journal of Biological Chemistry. 288: 5443-50
Panjarian S, Iacob RE, Chen S, et al. (2013) Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29
Panjarian SB, Iacob R, Shugui C, et al. (2013) Abstract 2221: Enhanced SH3:linker interaction allosterically sensitizes Abl kinases to small molecule inhibitors. Cancer Research. 73: 2221-2221
Panjarian SB, Chen S, Iacob R, et al. (2012) Abstract 5599: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction Cancer Research. 72: 5599-5599
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