Anne Gangloff, Ph.D.

Affiliations: 
2002 Universite Laval (Canada) 
Area:
Biochemistry, Animal Physiology Biology
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"Anne Gangloff"
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Sheng-Xiang Lin grad student 2002 Universite Laval (Canada)
 (Etudes des relations structure/fonction et de l'activite 17beta-hydroxysteroide deshydrogenase chez les enzymes 17beta-hydroxysteroide deshydrogenase type 1 et 3alpha-hydroxysteroide deshydrogenase type 3 humaines.)
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Publications

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Nahoum V, Gangloff A, Shi R, et al. (2003) How estrogen-specific proteins discriminate estrogens from androgens: a common steroid binding site architecture. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1334-6
Gangloff A, Shi R, Nahoum V, et al. (2003) Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 274-6
Qiu W, Campbell RL, Gangloff A, et al. (2002) A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1829-31
Zhou M, Qiu W, Chang HJ, et al. (2002) Purification, crystallization and preliminary X-ray diffraction results of human 17beta-hydroxysteroid dehydrogenase type 5. Acta Crystallographica. Section D, Biological Crystallography. 58: 1048-50
Nahoum V, Gangloff A, Legrand P, et al. (2001) Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. The Journal of Biological Chemistry. 276: 42091-8
Gangloff A, Garneau A, Huang YW, et al. (2001) Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction. The Biochemical Journal. 356: 269-76
Lin SX, Han Q, Azzi A, et al. (2000) 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids. The Journal of Steroid Biochemistry and Molecular Biology. 73: 183
Han Q, Campbell RL, Gangloff A, et al. (2000) Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain. The Journal of Biological Chemistry. 275: 1105-11
Lin SX, Han Q, Azzi A, et al. (1999) 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids. The Journal of Steroid Biochemistry and Molecular Biology. 69: 425-9
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