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Ningyu Chen, Ph.D.

Affiliations: 
2001 University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Molecular Biology, Genetics
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Lester F. Lau grad student 2001 University of Illinois, Chicago
 (Identification and function of the Cyr61 receptors in human skin fibroblasts.)

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Publications

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Chen CC, Young JL, Monzon RI, et al. (2007) Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. The Embo Journal. 26: 1257-67
Leu SJ, Chen N, Chen CC, et al. (2004) Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions. The Journal of Biological Chemistry. 279: 44177-87
Chen N, Leu SJ, Todorovic V, et al. (2004) Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. The Journal of Biological Chemistry. 279: 44166-76
Leu SJ, Liu Y, Chen N, et al. (2003) Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). The Journal of Biological Chemistry. 278: 33801-8
Lin CG, Leu SJ, Chen N, et al. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. The Journal of Biological Chemistry. 278: 24200-8
Grzeszkiewicz TM, Lindner V, Chen N, et al. (2002) The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans. Endocrinology. 143: 1441-1450
Schober JM, Chen N, Grzeszkiewicz TM, et al. (2002) Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood. 99: 4457-65
Grzeszkiewicz TM, Lindner V, Chen N, et al. (2002) The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology. 143: 1441-50
Grzeszkiewicz TM, Kirschling DJ, Chen N, et al. (2001) CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. The Journal of Biological Chemistry. 276: 21943-50
Chen CC, Chen N, Lau LF. (2001) The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. The Journal of Biological Chemistry. 276: 10443-52
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