John F. Reichard, Ph.D.

Affiliations: 
2004 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Toxicology
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Dennis R. Petersen grad student 2004 University of Colorado, Denver
 (Electrophile-mediated antioxidant response in hepatic stellate cells: Involvement of 4-hydroxy-2-nonenal in liver fibrosis and phase II metabolism.)
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Publications

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Keenan AB, Jenkins SL, Jagodnik KM, et al. (2018) The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Systems. 6: 13-24
Dourson M, Reichard J, Nance P, et al. (2014) Mode of action analysis for liver tumors from oral 1,4-dioxane exposures and evidence-based dose response assessment. Regulatory Toxicology and Pharmacology : Rtp. 68: 387-401
Budinsky RA, Schrenk D, Simon T, et al. (2014) Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study. Critical Reviews in Toxicology. 44: 83-119
Chen J, Hu Z, Phatak M, et al. (2013) Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. Plos Computational Biology. 9: e1003198
States JC, Barchowsky A, Cartwright IL, et al. (2011) Arsenic toxicology: translating between experimental models and human pathology. Environmental Health Perspectives. 119: 1356-63
Reichard JF, Puga A. (2010) Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics. 2: 87-104
Sartor MA, Schnekenburger M, Marlowe JL, et al. (2009) Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environmental Health Perspectives. 117: 1139-46
Reichard JF, Sartor MA, Puga A. (2008) BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. The Journal of Biological Chemistry. 283: 22363-70
Reichard JF, Motz GT, Puga A. (2007) Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Research. 35: 7074-86
Reichard JF, Petersen DR. (2006) Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation. Archives of Biochemistry and Biophysics. 446: 111-8
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