Silvia L. Delker, Ph.D.
Affiliations: | 2009 | Biological Sciences - Ph.D. | University of California, Irvine, Irvine, CA |
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Molecular BiologyGoogle:
"Silvia Delker"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Thomas L. Poulos | grad student | 2009 | UC Irvine | |
| (Delineating the structural basis of ligand binding within constitutive nitric oxide synthases: An analysis of isoform selective inhibitors crystallographically, enzymatically, and computationally.) | ||||
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Publications
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| Basak S, Li Y, Tao S, et al. (2022) Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors. Journal of Medicinal Chemistry |
| Riggs JR, Nagy M, Elsner J, et al. (2017) The discovery of a dual TTK protein kinase/ CDC2-like kinase (CLK2) inhibitor for the treatment of triple negative breast cancer initiated from a phenotypic screen. Journal of Medicinal Chemistry |
| Chamberlain P, Delker S, Pagarigan B, et al. (2014) Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes. Plos One. 9: e103638 |
| Chamberlain PP, Lopez-Girona A, Miller K, et al. (2014) Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nature Structural & Molecular Biology. 21: 803-9 |
| Li H, Jamal J, Delker S, et al. (2014) The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry. 53: 5272-9 |
| Delker S, Robinson D, Bahmanyar S, et al. (2014) Inhibitor Binding Mode Differences Within the AGC Subfamily Acta Crystallographica Section a Foundations and Advances. 70: C1640-C1640 |
| Li H, Xue F, Kraus JM, et al. (2013) Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343 |
| Plantevin Krenitsky V, Nadolny L, Delgado M, et al. (2012) Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 1433-8 |
| Xue F, Kraus JM, Labby KJ, et al. (2011) Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403 |
| Xue F, Fang J, Delker SL, et al. (2011) Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048 |