Matthew D. Daugherty, Ph.D.

Affiliations: 
2009 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
Molecular Biology, General Biophysics
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Parents

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Alan D. Frankel grad student 2009 UCSF
 (Function and structure of HIV-1 Rev.)
Harmit Singh Malik post-doc UCSD (FlyTree)
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Publications

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Tsu BV, Beierschmitt C, Ryan AP, et al. (2021) Diverse viral proteases activate the NLRP1 inflammasome. Elife. 10
Daugherty MD, Zanders SE. (2019) Gene conversion generates evolutionary novelty that fuels genetic conflicts. Current Opinion in Genetics & Development. 58: 49-54
Chavarría-Smith J, Mitchell PS, Ho AM, et al. (2016) Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. Plos Pathogens. 12: e1006052
Daugherty MD, Schaller AM, Geballe AP, et al. (2016) Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. Elife. 5
Chou S, Daugherty MD, Peterson SB, et al. (2015) Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature. 518: 98-101
Daugherty MD, Malik HS. (2014) How a virus blocks a cellular emergency access lane to the nucleus, STAT! Cell Host & Microbe. 16: 150-2
Daugherty MD, Young JM, Kerns JA, et al. (2014) Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts. Plos Genetics. 10: e1004403
Tenthorey JL, Kofoed EM, Daugherty MD, et al. (2014) Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Molecular Cell. 54: 17-29
Carter JJ, Daugherty MD, Qi X, et al. (2013) Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. Proceedings of the National Academy of Sciences of the United States of America. 110: 12744-9
Daugherty MD, Malik HS. (2012) Rules of engagement: molecular insights from host-virus arms races. Annual Review of Genetics. 46: 677-700
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