Nicole Brufatto, Ph.D.

Affiliations: 
2003 Queen's University, Canada, Kingston, Ontario, Canada 
Area:
Biochemistry
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"Nicole Brufatto"
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Michael E. Nesheim grad student 2003 Queen's University, Canada
 (The enzymology and regulation of prothrombinase.)
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Publications

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Cochrane A, Murley LL, Gao M, et al. (2009) Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology. 388: 103-11
Gao M, Brufatto N, Chen T, et al. (2005) Expression profiling of herpesvirus and vaccinia virus proteins using a high-throughput baculovirus screening system. Journal of Proteome Research. 4: 2225-35
Bukys MA, Blum MA, Kim PY, et al. (2005) Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa. The Journal of Biological Chemistry. 280: 27393-401
Dennis MW, Downey C, Brufatto N, et al. (2004) Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein Thrombosis and Haemostasis. 91: 522-530
Orfeo T, Brufatto N, Nesheim ME, et al. (2004) The factor V activation paradox. The Journal of Biological Chemistry. 279: 19580-91
Schneider M, Brufatto N, Neill E, et al. (2004) Activated thrombin-activatable fibrinolysis inhibitor reduces the ability of high molecular weight fibrin degradation products to protect plasmin from antiplasmin. The Journal of Biological Chemistry. 279: 13340-5
Brufatto N, Ward A, Nesheim ME. (2003) Factor Xa is highly protected from antithrombin-fondaparinux and antithrombin-enoxaparin when incorporated into the prothrombinase complex. Journal of Thrombosis and Haemostasis : Jth. 1: 1258-63
Brufatto N, Nesheim ME. (2003) Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process. The Journal of Biological Chemistry. 278: 6755-64
Nesheim M, Samis J, Walker J, et al. (2002) Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients Blood Reviews. 16: S15-22
Toh CH, Samis J, Downey C, et al. (2002) Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca ++-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation Blood. 100: 2522-2529
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