Lokesh Gakhar, Ph.D.

Affiliations: 
2003 University of Iowa, Iowa City, IA 
Area:
Structural Biology
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"Lokesh Gakhar"
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Parents

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John M. Wiencek grad student 2003 University of Iowa
 (Ice formation in flash cooled protein crystals.)
Paul McCray post-doc (Bronchopulmonary Tree)
Ramaswamy Subramanian post-doc (Crystallography Tree)

Collaborators

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Christopher A. Ahern collaborator (Physics Tree)
Zeynep Akyol Ataman collaborator
Michael A. Apicella collaborator (Microtree)
Nikolai O. Artemyev collaborator
Jennifer A. Bartlett collaborator (Bronchopulmonary Tree)
Alexander G. Bassuk collaborator (Cell Biology Tree)
Ryan L. Boudreau collaborator (Neurotree)
Craig D. Ellermeier collaborator (Microtree)
Michael D. Feldkamp collaborator
Bret D. Freudenthal collaborator (Cell Biology Tree)
Ernesto J. Fuentes collaborator
Jon C. Houtman collaborator
Chou-Long Huang collaborator (Neurotree)
Amnon Kohen collaborator
Damian Krysan collaborator (Microtree)
Vinit B. Mahajan collaborator (Cell Biology Tree)
Robert Piper collaborator (Cell Biology Tree)
Madeline A. Shea collaborator
Maria Spies collaborator
Mani Subramanian collaborator (E-Tree)
Ryan M. Summers collaborator (E-Tree)
Susan E. Tsutakawa collaborator
M. Todd Washington collaborator (Cell Biology Tree)
BETA: Related publications

Publications

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Beattie SR, Schnicker NJ, Murante T, et al. (2020) Benzothiourea derivates target the secretory pathway of the human fungal pathogen Cryptococcus neoformans. Acs Infectious Diseases
Velez G, Sun YJ, Khan S, et al. (2020) Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants. Cell Reports. 30: 881-892.e5
Sathyanarayanan N, Cannone G, Gakhar L, et al. (2019) Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway. Nature Communications. 10: 4127
Srivastava D, Gakhar L, Artemyev NO. (2019) Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor. Nature Communications. 10: 3084
Li Q, Gakhar L, Ashley Spies M. (2018) Determinants of human Glucokinase activation and implications for small molecule allosteric control. Biochimica Et Biophysica Acta
Cho C, Chande AT, Gakhar L, et al. (2018) Characterization of a nontypeable Haemophilus influenzae thermonuclease. Plos One. 13: e0197010
Velez G, Bassuk AG, Schaefer KA, et al. (2018) A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay. Cold Spring Harbor Molecular Case Studies
Vance NR, Spies MA, Gakhar L. (2017) Allosteric Tuning of Caspase-7: a Fragment-Based Drug Discovery Approach. Angewandte Chemie (International Ed. in English)
Xu Z, Gakhar L, Bain FE, et al. (2017) The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain. The Journal of Biological Chemistry
Liu X, Speckhard DC, Shepherd TR, et al. (2016) Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure (London, England : 1993). 24: 2053-2066
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