Alan V. Smrcka

University of Rochester, Rochester, NY 
Pharmacology, Biochemistry
"Alan Victor Smrcka"

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Richard G. Jensen grad student 1984-1990 University of Arizona
 (Structural and evolutionary factors affecting the tight binding of inhibitors by ribulose 1,5-bisphosphate carboxylase/oxygenase.)
Paul C. Sternweis post-doc 1990-1994 UT Southwestern


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Naincy R Chandan grad student 2016- University of Michigan
Wenhui Wei grad student 2017- Rochester
Daniel M. Yoshikawa grad student 2001 Rochester
Junhao Mao grad student 2002 Rochester
Tabetha M. Bonacci grad student 2006 Rochester
Huan Wang grad student 2000-2006 Rochester
Chujun Yuan grad student 2002-2007 Rochester
Emily A. Oestreich grad student 2008 Rochester
Axel L. Dessal grad student 2010 Rochester
Aththanyake M. Seneviratne grad student 2010 Rochester
Lianghui Zhang grad student 2013 Rochester
Wei Kan grad student 2014 Rochester
Chinmay Surve grad student 2011-2015 Rochester
Jesi Lee Anne grad student 2013-2018 Rochester
Rafael Gil de Rubio grad student 2013-2018 Rochester
Jerry Madukwe grad student 2015-2018 Rochester
Isaac Fisher grad student 2014-2019 Rochester
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Wei W, Smrcka AV. (2023) Internalized β2-Adrenergic Receptors Inhibit Subcellular Phospholipase C-Dependent Cardiac Hypertrophic Signaling. Biorxiv : the Preprint Server For Biology
Lefevre TJ, Wei W, Mukhaleva E, et al. (2023) Stabilization of Interdomain Interactions in G protein α Subunits Determines Gα Subtype Signaling Specificity. Biorxiv : the Preprint Server For Biology
Wei W, Smrcka AV. (2022) Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease. Journal of Cardiovascular Pharmacology
Phan HTN, Loomis J, Abraham S, et al. (2022) A Naturally Occurring Membrane-Anchored Gα Variant, XLαs, Activates Phospholipase Cβ4. The Journal of Biological Chemistry. 102134
Chandan NR, Abraham S, SenGupta S, et al. (2022) A network of Gα signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF. Science Signaling. 15: eabi9869
Phan HTN, Kim NH, Wei W, et al. (2021) Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis. Science Signaling. 14: eabj4243
Knight KM, Ghosh S, Campbell SL, et al. (2021) A universal allosteric mechanism for G protein activation. Molecular Cell
Fisher IJ, Jenkins ML, Tall GG, et al. (2020) Activation of Phospholipase C β by Gβγ and Gα Involves C-Terminal Rearrangement to Release Autoinhibition. Structure (London, England : 1993)
Cash JN, Chandan NR, Hsu AY, et al. (2020) Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils. Molecular Pharmacology
Chandan NR, Abraham S, Smrcka AV. (2020) Identification of PDZ‐RhoGEF as a Novel Target of Gα i Signaling The Faseb Journal. 34: 1-1
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