Rick H. Cote, Ph.D.

Affiliations: 
1988-2008 Biochemistry University of New Hampshire, Durham, NH, United States 
 2008- Molecular, Cellular, and Biomedical Sciences University of New Hampshire, Durham, NH, United States 
Area:
Biochemistry, Neuroscience, Pharmacology
Website:
www.cotelab.org
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"Rick Cote"
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Parents

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Abraham L. Sonenshein research assistant 1973-1974 Tufts University Medical School
Gary G. Borisy grad student 1974-1980 UW Madison
Deric Bownds post-doc 1980-1986 UW Madison

Children

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Suzanne Matte research assistant 2008- UNH
Carol Macomber research assistant 1988-1990 UNH
Maura Brunnock Shipman research assistant 1990-1992 UNH
JoAnn Martin research assistant 1992-1995 UNH
Karen Sanborn research assistant 1995-1997 UNH
Suzanne Hosier research assistant 2003-2005 UNH
Michael J. Irwin grad student 2015- UNH
Richa Gupta grad student 2016- UNH
Kranti Galande grad student 2018- UNH
Vincent J. Coccia grad student 1995 UNH
Marc D'Amours grad student 1997 UNH
Amy Daly grad student 1997 UNH
Jay Grazio grad student 1997 UNH
Carmen Maftei grad student 2000 UNH
Hongmei Mou grad student 2001 UNH
Angela W. Norton grad student 2002 UNH
Michael J. Paglia grad student 2002 UNH
Jennifer Terew grad student 2005 UNH
Beverly Valeriani grad student 2005 UNH
Dana C. Pentia grad student 2006 UNH
Yuting Liu grad student 2007 UNH
Hannah Gitschier grad student 2011 UNH
Wei Yao grad student 2013 UNH
Xiongzhuo Gao grad student 2010-2016 UNH
Wen Xi grad student 2016-2017 UNH
Kevin D. Schuster grad student 2012-2019 UNH
Xin Wang post-doc 2016- UNH
Qing Feng post-doc 2002-2003 UNH
Cosma Dellisanti post-doc 2013-2014 UNH
Xiujun Zhang research scientist 2009-2013 UNH
Karyn B. Cahill research scientist 2008-2015 UNH
BETA: Related publications

Publications

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Cote RH, Gupta R, Irwin MJ, et al. (2021) Photoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases. Advances in Experimental Medicine and Biology
Gupta R, Liu Y, Wang H, et al. (2020) Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. Journal of Molecular Biology
Irwin MJ, Gupta R, Gao XZ, et al. (2019) The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation. The Journal of Biological Chemistry
Chu F, Hogan D, Gupta R, et al. (2019) Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry. Journal of Molecular Biology
Wang X, Plachetzki DC, Cote RH. (2019) The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation. The Journal of Biological Chemistry
Schuster KD, Mohammadi M, Cahill KB, et al. (2019) Pharmacological and molecular dynamics analyses of differences in inhibitor binding to human and nematode PDE4: Implications for management of parasitic nematodes. Plos One. 14: e0214554
Zeng-Elmore X, Gao XZ, Pellarin R, et al. (2014) Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling. Journal of Molecular Biology. 426: 3713-28
Zeng-Elmore X, Tang Y, Gao X, et al. (2014) Modeling of the phosphodiesterase (PDE6) Journal of Molecular Biology. 426: 3713-3728
Schuster KD, Cahill KB, Morris K, et al. (2013) PDE inhibitors as potential pesticides targeting parasitic nematodes The Faseb Journal. 27
Cahill KB, Quade JH, Carleton KL, et al. (2012) Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6. The Journal of Biological Chemistry. 287: 41406-16
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