Shen-En Chen, Ph.D.

2008 Chemistry and Biochemistry Baylor University, Waco, TX 
Biochemistry, Physical Chemistry
"Shen-En Chen"
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Mary L. Trawick grad student 2008 Baylor University
 (Modeling, design, and development of potential inhibitors of gamma-glutamylamine cyclotransferase and inhibitors of cruzain as therapeutic agents for Chagas' disease.)
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Thanigaimalai P, Konno S, Yamamoto T, et al. (2013) Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies. European Journal of Medicinal Chemistry. 68: 372-84
Thanigaimalai P, Konno S, Yamamoto T, et al. (2013) Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study. European Journal of Medicinal Chemistry. 65: 436-47
Konno S, Thanigaimalai P, Yamamoto T, et al. (2013) Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety. Bioorganic & Medicinal Chemistry. 21: 412-24
Song J, Jones LM, Kumar GD, et al. (2012) Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L. Acs Medicinal Chemistry Letters. 3: 450-3
Chavarria GE, Horsman MR, Arispe WM, et al. (2012) Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. European Journal of Medicinal Chemistry. 58: 568-72
Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, et al. (2010) Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1415-9
Trawick ML, Arispe‐Angulo WM, Chen S, et al. (2007) Kinetics of Thiosemicarbazone‐Based Inhibitors of Cathepsin L The Faseb Journal. 21
Chen S, Siles RE, Zhou M, et al. (2007) Kinetic Studies of Potent Thiosemicarbazone Inhibitors of Cruzain The Faseb Journal. 21
Siles R, Chen SE, Zhou M, et al. (2006) Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 16: 4405-9
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