Manju M. Hingorani

Affiliations: 
Wesleyan University, Middletown, CT, United States 
Area:
General Biophysics, Biochemistry
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"Manju Hingorani"
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Parents

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Smita S. Patel grad student 1996 Ohio State
 (Role of Hexameric Structure and dTTPase Activity in Bacteriophage T7 Helicase-Catalyzed Unwinding of Double-Stranded DNA.)
Michael E. O'Donnell post-doc Rockefeller

Children

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Edwin Antony grad student 2005 Wesleyan
Maria-Magdalena Coman grad student 2007 Wesleyan
Siying Chen grad student 2008 Wesleyan
Jie Zhai grad student 2011 Wesleyan
Yayan Zhou grad student 2012 Wesleyan
Anushi Sharma grad student 2014 Wesleyan
Bo Song grad student 2018 Wesleyan
Brandon Case grad student 2019 Wesleyan
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Publications

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Jayaraj A, Thayer KM, Beveridge DL, et al. (2023) Molecular Dynamics of Mismatch Detection - How MutS Uses Indirect Readout to Find Errors in DNA. Biophysical Journal
Hao P, LeBlanc SJ, Case BC, et al. (2020) Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby. Proceedings of the National Academy of Sciences of the United States of America
Lombardo Z, Lahiri S, Lakhani B, et al. (2020) Investigating the Role of Msh4-Msh5 ATPASE Activity During Homologous Recombination Biophysical Journal. 118: 73a
Li Y, Lombardo Z, Joshi M, et al. (2019) Mismatch Recognition by Msh2-Msh6: Role of Structure and Dynamics. International Journal of Molecular Sciences. 20
Case BC, Hartley S, Osuga M, et al. (2019) The ATPase mechanism of UvrA2 reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair. Nucleic Acids Research
Qiu R, DeRocco VC, Harris C, et al. (2019) Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling. The Embo Journal. 38
Lahiri S, Li Y, Hingorani MM, et al. (2018) MutSγ-Induced DNA Conformational Changes Provide Insights into its Role in Meiotic Recombination. Biophysical Journal
LeBlanc SJ, Gauer JW, Hao P, et al. (2018) Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS. Nucleic Acids Research
Song B, Hamdan SM, Hingorani MM. (2018) Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage. The Journal of Biological Chemistry
Zaher MS, Rashid F, Song B, et al. (2018) Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway. Nucleic Acids Research
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