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Joseph T. Jarrett

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry
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"Joseph Jarrett"
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Jason T. Wan grad student 2005 Penn
Michael R. Reyda grad student 2007 Penn

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Tao L, Stich TA, Fugate CJ, et al. (2018) EPR-Derived Structure of a Paramagnetic Intermediate Generated by Biotin Synthase BioB. Journal of the American Chemical Society
Cramer JD, Jarrett JT. (2018) Purification, Characterization, and Biochemical Assays of Biotin Synthase From Escherichia coli. Methods in Enzymology. 606: 363-388
Jarrett JT. (2015) The biosynthesis of thiol- and thioether-containing cofactors and secondary metabolites catalyzed by radical S-adenosylmethionine enzymes. The Journal of Biological Chemistry. 290: 3972-9
Jarrett JT. (2014) Biotin synthase: A role for iron-sulfur clusters in the radical-mediated generation of carbon-sulfur bonds Iron-Sulfur Clusters in Chemistry and Biology. 107-132
Fugate CJ, Stich TA, Kim EG, et al. (2012) 9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli. Journal of the American Chemical Society. 134: 9042-5
Fugate CJ, Jarrett JT. (2012) Biotin synthase: insights into radical-mediated carbon-sulfur bond formation. Biochimica Et Biophysica Acta. 1824: 1213-22
Taylor AM, Stoll S, Britt RD, et al. (2011) Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry. 50: 7953-63
Reyda MR, Fugate CJ, Jarrett JT. (2009) A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly. Biochemistry. 48: 10782-92
Farrar CE, Jarrett JT. (2009) Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase. Biochemistry. 48: 2448-58
Taylor AM, Farrar CE, Jarrett JT. (2008) 9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase. Biochemistry. 47: 9309-17
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