Jeffrey F. Ohren, Ph.D.

Affiliations: 
2007 The University of Toledo 
Area:
Biochemistry
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"Jeffrey Ohren"
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Ronald E. Viola grad student 2007 The University of Toledo
 (Structural and functional studies of aspartate beta-semialdehyde dehydrogenase, aspartokinase and creatine kinase.)
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Publications

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Ohren J, Parungao GG, Viola RE. (2019) Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum. Acta Crystallographica. Section F, Structural Biology Communications. 75: 290-298
Han S, Czerwinski RM, Caspers NL, et al. (2014) Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors. The Biochemical Journal. 460: 211-22
Viola RE, Liu X, Ohren JF, et al. (2008) The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae. Acta Crystallographica. Section D, Biological Crystallography. 64: 321-30
Evdokimov AG, Mekel M, Hutchings K, et al. (2008) Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus. Journal of Structural Biology. 162: 152-69
Miller JR, Ohren J, Sarver RW, et al. (2007) Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis. Journal of Bacteriology. 189: 8196-205
Ohren JF, Kundracik ML, Borders CL, et al. (2007) Structural asymmetry and intersubunit communication in muscle creatine kinase. Acta Crystallographica. Section D, Biological Crystallography. 63: 381-9
Bilder P, Lightle S, Bainbridge G, et al. (2006) The structure of the carboxyltransferase component of acetyl-CoA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme Biochemistry. 45: 1712-1722
Faehnle CR, Ohren JF, Viola RE. (2005) A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii. Journal of Molecular Biology. 353: 1055-68
Habel JE, Ohren JF, Borgstahl GE. (2001) Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association. Acta Crystallographica. Section D, Biological Crystallography. 57: 254-9
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