Lesa J. Beamer

Affiliations: 
University of Missouri - Columbia, Columbia, MO, United States 
Area:
Biochemistry
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"Lesa Beamer"
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Publications

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Stiers KM, Kain BN, Graham AC, et al. (2016) Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. Journal of Molecular Biology
Xu J, Lee Y, Beamer LJ, et al. (2015) Phosphorylation in the catalytic cleft stabilizes and attracts domains of a phosphohexomutase. Biophysical Journal. 108: 325-37
Lee Y, Stiers KM, Kain BN, et al. (2014) Compromised catalysis and potential folding defects in in vitro studies of missense mutants associated with hereditary phosphoglucomutase 1 deficiency. The Journal of Biological Chemistry. 289: 32010-9
Wei Y, Marcink TC, Xu J, et al. (2014) Chemical shift assignments of domain 4 from the phosphohexomutase from Pseudomonas aeruginosa suggest that freeing perturbs its coevolved domain interface. Biomolecular Nmr Assignments. 8: 329-33
Hu L, Magesh S, Chen L, et al. (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters. 23: 3039-43
Sarma AV, Anbanandam A, Kelm A, et al. (2012) Solution NMR of a 463-residue phosphohexomutase: domain 4 mobility, substates, and phosphoryl transfer defect. Biochemistry. 51: 807-19
Chuang GY, Mehra-Chaudhary R, Ngan CH, et al. (2010) Domain motion and interdomain hot spots in a multidomain enzyme. Protein Science : a Publication of the Protein Society. 19: 1662-72
Schramm AM, Karr D, Mehra-Chaudhary R, et al. (2010) Breaking the covalent connection: Chain connectivity and the catalytic reaction of PMM/PGM. Protein Science : a Publication of the Protein Society. 19: 1235-42
Lo SC, Li X, Henzl MT, et al. (2006) Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. The Embo Journal. 25: 3605-17
Regni C, Shackelford GS, Beamer LJ. (2006) Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 722-6
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