Donovan C. Haines

Affiliations: 
2001-2008 University of Texas at Dallas, Richardson, TX, United States 
 2008- Sam Houston State University, Huntsville, TX, United States 
Area:
Biochemistry
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"Donovan Haines"
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Publications

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Davydov DR, Ponomarev GV, Bobrovnikova-Marjon E, et al. (2013) Aluminum-substituted heme domain of P450BM-3 (BMP): introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450. Biotechnology and Applied Biochemistry. 60: 41-51
Marziaz ML, Frazier K, Guidry PB, et al. (2013) Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD(50) yields insight into the efficacy of prophylactics. Journal of Applied Toxicology : Jat. 33: 50-5
De Matteis F, Ballou DP, Coon MJ, et al. (2012) Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling. Biochemical Pharmacology. 84: 374-82
Haines DC, Hegde A, Chen B, et al. (2011) A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation. Biochemistry. 50: 8333-41
Horke S, Witte I, Altenhöfer S, et al. (2010) Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin. The Biochemical Journal. 426: 73-83
Chowdhary PK, Stewart L, Lopez C, et al. (2008) A single mutation in P450BM-3 enhances acyl homoserine lactone: acyl homoserine substrate binding selectivity nearly 250-fold. Journal of Biotechnology. 135: 374-6
Teiber JF, Horke S, Haines DC, et al. (2008) Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone. Infection and Immunity. 76: 2512-9
Haines DC, Chen B, Tomchick DR, et al. (2008) Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel. Biochemistry. 47: 3662-70
Chowdhary PK, Keshavan N, Nguyen HQ, et al. (2007) Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines. Biochemistry. 46: 14429-37
Hegde A, Haines DC, Bondlela M, et al. (2007) Interactions of substrates at the surface of P450s can greatly enhance substrate potency. Biochemistry. 46: 14010-7
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