Tad Harbison Koch, Ph.D.

Affiliations: 
1968- Chemistry University of Colorado, Boulder, Boulder, CO, United States 
Area:
Biochemistry, Pharmaceutical Chemistry, nucleic acids
Website:
http://www.colorado.edu/chembio/tad-koch
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"Tad Koch"
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Parents

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Orville L. Chapman grad student 1964-1968 Iowa State

Children

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Thomas Price Kirby grad student 2014- CU Boulder
Patrick J. Burke grad student 2003 CU Boulder
Glen C. Post grad student 2006 CU Boulder
Brian T. Kalet grad student 2007 CU Boulder
Ben Barthel grad student 2008 CU Boulder
Daniel L. Rudnicki grad student 2012 CU Boulder
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Publications

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Ganesh AN, Aman A, Logie J, et al. (2019) Colloidal drug aggregate stability in high serum conditions and pharmacokinetic consequence. Acs Chemical Biology
Ganesh AN, Logie J, McLaughlin CK, et al. (2017) Leveraging colloidal aggregation for drug-rich nanoparticle formulations. Molecular Pharmaceutics
Barthel BL, Mooz EL, Wiener LE, et al. (2016) Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde. Journal of Medicinal Chemistry. 59: 2205-21
Xiao D, Shi D, Yang D, et al. (2013) Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs. Biochemical Pharmacology. 85: 439-47
Barthel BL, Rudnicki DL, Kirby TP, et al. (2012) Synthesis and biological characterization of protease-activated prodrugs of doxazolidine. Journal of Medicinal Chemistry. 55: 6595-607
Gold L, Ayers D, Bertino J, et al. (2010) Aptamer-based multiplexed proteomic technology for biomarker discovery. Plos One. 5: e15004
Barthel BL, Zhang Z, Rudnicki DL, et al. (2009) Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine. Journal of Medicinal Chemistry. 52: 7678-88
Koch TH, Barthel BL, Kalet BT, et al. (2008) Anthracycline-formaldehyde conjugates and their targeted prodrugs. Topics in Current Chemistry. 283: 141-70
Barthel BL, Torres RC, Hyatt JL, et al. (2008) Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug Journal of Medicinal Chemistry. 51: 298-304
Spencer DM, Bilardi RA, Koch TH, et al. (2008) DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair. Mutation Research. 638: 110-21
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