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Ronald T. Borchardt

Affiliations: 
Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmaceutical Chemistry
Website:
https://pharmchem.ku.edu/ronald-borchardt-0
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"Ronald T. Borchardt"
Bio:

DOI: 10.1002/jps.24687

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Parents

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Edward Ervin Smissman grad student 1970 University of Kansas
 (A stereochemical approach to the adrenergic system.)

Children

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Jinnian Gao grad student 2000 University of Kansas
Erin D. Hugger grad student 2002 University of Kansas
Bianca M. Liederer grad student 2005 University of Kansas
Daniel R. Mudra grad student 2007 University of Kansas
Rebecca A. Nofsinger grad student 2008 University of Kansas
Donald Wayne Miller post-doc University of Kansas School of Pharmacy (Neurotree)
Binghe Wang post-doc 1992-1993 University of Kansas

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Publications

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Trammel AM, Simmons JE, Borchardt RT. (2013) An efficient in vitro assay for acetylcholinesterase reactivators using immobilized enzyme. Pharmaceutical Research. 1: 115-20
Nofsinger R, Fuchs-Knotts T, Borchardt RT. (2012) Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism. Journal of Pharmaceutical Sciences. 101: 3486-99
Nofsinger R, Borchardt RT. (2012) Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa. Journal of Pharmaceutical Sciences. 101: 3500-10
Wang B, Shan D, Wang W, et al. (2012) Synthesis of coumarin-based, esterase-sensitive cyclic prodrugs of opioid peptides with enhanced membrane permeability and enzymatic stability. Methods in Molecular Medicine. 23: 71-85
Wang B, Gangwar S, Pauletti G, et al. (2012) Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using a 3-(2'-hydroxy-4',6'-dimethylphenyl)-3,3-dimethyl propionic Acid promoiety. Methods in Molecular Medicine. 23: 53-69
Gangwar S, Pauletti GM, Siahaan TJ, et al. (2012) Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using an acyloxyalkoxy promoiety. Methods in Molecular Medicine. 23: 37-51
Mudra DR, Jin JY, Borchardt RT. (2010) Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 999-1015
Mudra DR, Borchardt RT. (2010) Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 982-98
Mudra DR, Borchardt RT. (2010) Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 1016-27
Wang B, Gangwar S, Pauletti G, et al. (2010) ChemInform Abstract: Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymic Stability Using a 3-(2′-Hydroxy-4′,6′-dimethylphenyl)-3,3-Dimethylpropionic Acid Promoiety Cheminform. 31: no-no
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